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NMN (NAD+) Therapy

What is NMN (NAD+) therapy?

NMN (full name is Nicotinamide Mononucleotide, also known as NAD+ precursor) is a key intermediate in the synthesis of Nicotinamide Adenine Dinucleotide (NAD+) – an essential enzyme for maintaining various important functions of the cell. Including metabolism, DNA repair, growth stimulation and maintaining cell survival.

When NMN enters the body, it will be absorbed and converted into NAD+ and activate the Sirtuins gene - the longevity gene. NAD+ is found in all organisms, affecting youth and health. NAD+ levels peak in late adolescence, gradually decrease after the age of 20 and decrease sharply after the age of 40. This therapy will supplement the deficient NAD+ source, thereby enhancing metabolism, creating energy for cells, significantly improving health through repairing mitochondria and DNA. Sirtuins are a group of NAD-dependent deacetylases, playing an important role in the aging process and longevity of humans. They have the effect of regulating the metabolic network to coordinate the cell's stress response. There are 7 types of Sirtuins in humans, SIRT1–7. This gene is often temporarily inactive when people enter adulthood. When Sirtuins are activated by NMN, they will return to normal function, helping to prevent aging and fight diseases thanks to the mechanism of gene repair at the molecular level. We use the method of intravenous infusion of high purity NMN (ingredient ratio 100%). Ensuring purity, sterility, and no endotoxins and mycoplasma. The advantage of this method is that the metabolism rate of intravenous infusion of NMN is 500 times faster than the pill form and many times higher than the NMN content in food. The product has the characteristic of unlocking molecules, creating energy immediately for cells. This is a source of primer to activate stem cells to work strongly, especially good for those who perform stem cell supplementation.

Some outstanding features

Stem cell therapy

Stem cells (SC) are pluripotent cells. In a certain environment, they have the ability to self-regenerate and differentiate according to certain functions.

Blood Purification

Blood purification therapy is an advanced treatment that helps prevent atherosclerosis, which can lead to strokes and heart attacks. It removes harmful substances from the blood and provides anti-aging benefits to blood vessels.

Exosomes Therapy

Exosomes are microscopic, structured particles produced during cell culture. Exosomes travel in body fluids such as blood, urine, saliva, etc.

Health Forecast

We provide a breakthrough solution to address aging concerns through advanced blood protein analysis. Our digital health service in Japan not only enables accurate detection and prediction of age-related conditions such as dementia, CKD, and various forms of stroke, but also prioritizes patient education for appropriate lifestyle changes. This technology aims to detect the possibility of future mortality so that customers can take early intervention and proactively prevent and protect their health to minimize the burden of disease and healthcare costs in the future.

Frequently Asked Questions

What are stem cells? What are the properties of stem cells?

WHAT ARE STEM CELLS?

Stem cells (SC) are multipotent cells. In a certain environment, they have the ability to self-regenerate and differentiate according to certain functions. According to the body's natural mechanism, when any cell or tissue is damaged, stem cells will automatically concentrate and move to that location to heal and restore the damage.

Stem Cell Technology brings outstanding value to the “Regenerative Medicine Technology” industry, with the ability to regenerate, replace, and repair defective and damaged cells. Stem cells are isolated and cultured in vitro to create healthy cells and then reinjected into the body.
human body is sampled. By this method, new cells will replace and repair damaged or dead cells. Therefore, Stem Cell Medical Technology is being used to treat incurable and dangerous diseases.

STEM CELL CHARACTERISTICS

Feature 1: Differentiation feature (Cells maintain function by undergoing symmetric and asymmetric division.)
Feature 2: Multi-functionality( Cells have the ability to differentiate into many types of cells. Including: unipotent cells, multipotent cells, and multipotent cells.)
Feature 3: Low autoimmunity( Stem cells are primitive cells that have not yet differentiated.)
Feature 4: Compatibility( Compatible with different bodies.)

What are the uses of stem cells?

Treatment of eye diseases:

In clinical studies and trials such as: macular degeneration, retinitis and optic nerve disorders.

Stem cells have the ability to repair and replace eye tissue cells and restore vision and function to the eyes.

Treatment of lung and respiratory diseases:

Perform autologous stem cell treatment for asthma, bronchitis, emphysema causing heart rhythm disorders.

Treatment of kidney disease:

Basic studies have shown that stem cells have the ability to differentiate differentiate into kidney-specific cells and renal parenchymal cells.
Therefore, the transplanted stem cells will successfully repair, replace or regenerate the kidney to maintain its working function.

Treatment of diseases related to the immune system:

Improve symptoms of immune-related diseases by using Stem Cells to regenerate the immune system, improve immune regulation of: liver disease, lupus erythematosus, rheumatoid arthritis and type 1 diabetes.

Cardiovascular disease:

Mainly atherosclerosis, vasculitis, vascular dysfunction, angiogenesis, myocardial infarction, etc. The most common is atherosclerosis.

Gynecological disorders:

Stem cells are one of the effective methods of treating infertility. Applied to some gynecological diseases: ovarian failure, endometrial damage.

Other:

Stem cells have the ability to repair, replace and improve the function of diseases of teeth, hair, skin wounds, endocrine disorders through the skin, and treat diseases of ectodermal function.

Stem cell sampling and culture process?

Adipose tissue stem cells are extracted fat that is separated, purified, cultured and cloned, used as precursor cells for fibroblasts, injected into the subcutaneous epidermis, below the blood vessels. By repairing, replacing, bringing about effective, improved skin, erasing wrinkles and scars.

TRIP 1

The client underwent cell sampling (mesenchymal fat cells) in the area behind the ear which took about 30 minutes.
Performing cell sampling behind the ear will ensure better aesthetics than taking it from the umbilical cord area.

TRIP 2

The client injects the selected stem cells into the body by drip or injection.
cultured from previously collected cell samples.
The procedure takes a maximum of 2 hours and the client can resume normal activities immediately.

Why should you choose Riso Clinic to provide stem cell services?

No. Stem cell therapy is an advanced technology, and facilities providing stem cell therapy must meet strict standards set by the Japanese government and must be licensed to operate. Riso Clinic is a regenerative medicine provider officially certified by the Ministry of Health, Labor and Welfare of Japan.

How many stem cells will be injected per treatment? Is there a limit?

In one treatment, you can get between 100 million and 200 million cells at a time. It can be injected intravenously, injected into the face and knees at the same time. In such cases, up to 200 million cells can be injected into each area.

How are stem cell samples collected?

Stem cells are harvested through a small incision of just a few millimeters in the abdomen or behind the ear. We use anesthesia, so there is no pain and no need for hospitalization. Patients can go home the same day.

Does stem cell therapy have any side effects?

We use the customer's own stem cells, so side effects are negligible. We strictly follow the safety regulations set by the Japanese government.

Is there any age limit for treatment?

There is no specific age limit, but it is recommended to receive treatment as early as possible. Receiving multiple treatments early can enhance the anti-aging effects and provide better results in repairing damaged tissues and preventing disease.

How many stem cells are collected per sample?

In one harvest, we can produce four aliquots of stem cells. Each aliquot can grow up to 400 million stem cells. Once aliquots are used, they cannot be reused. Once all of these aliquots are used up, a new sampling must be performed.

How many times do I need to go to Japan?

If this is your first time using stem cell therapy, you will need to come to Japan twice — once to have your stem cells collected and once to have the stem cells injected into your body. After the initial sample is collected, you will not need to have further samples taken until all of the stem cells collected have been used.

How long does it take between sample collection and stem cell injection?

At least one month. After the cell sample is collected, it takes about one month for the cells to grow and develop to the required number. You need to schedule your injection and confirm it at least one month in advance of your desired treatment date.

How long does it take to take a cell sample?

Cell sampling time takes about 30 minutes.

Do I need to rest after having a cytology sample taken?

Depending on your health condition, you can move around normally.

How long does stem cell infusion take?

Stem cell infusion time is about 2 hours.

Do I need to rest after a stem cell infusion?

Depending on your health condition, you can move around normally. Avoid strenuous activities such as sports for 3 days from the date of implementation.